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ECE 454/554 - Introduction to Bioelectrics
The topics of 'Bioelectrics' are diverse and many. The Department of Electrical and Computer Engineering offers a course, which introduces students into the subject.
Since a comprehensive treatment of the fast moving field is impossible, the course intends to lay a foundation, that will allow biology and engineering
students to coomunicate effectively with each other. Equipped with a basic knowledge of the biological and engineering concepts of biolectrical phenomena, the
electrical activity, diagnostic and stimulation of the heart will be discussed in greater depth as a selected important 'main-stream' example. In the last part of the course,
selected current resarch topics of Bioelectrics are introduced. In particular during this last section, guest-speakers - experts in their respective fields - will give the individual lectures.
However, also for earlier sections, guests from Eastern Virginia Medical School and the Computational Research Group
are invited for keynote lectures.
Typical topics to be covered include:
- Electrical characteristics of excitable and non-excitable cells
- Propagation of electrical stimuli in nerves and muscles
- Circuit representations of cells
- Electrical models for signal-propagation
- Approaches for modeling of bioelectrical systems
- Experimental techniques (e.g. patch-clamp)
- Health risks of cell phone use
- Electrocardiography, cardiac pacing and defibrillation
- Electrotherapies for injuries (e.g. of the spinal cord)
- Plasma medicine
- Electroporation therapies (e.g. for gene transfer)
- Manipulation of cells and tissues by nanosecond pulsed electric fields (e.g. as cancer therapy)
Contributers/Guest-Speakers Fall 2010:
- Dr. Stephen Beebe, Center for Bioelectrics, ODU
- Dr. Frank Lattanzio, Dept. Pharmacology, EVMS
- Dr. Dean Kruszinski, Dept. Electrical and Computer Engineering, ODU
- Dr. Michael Stacey, Center for Bioelectrics, ODU
Topics/Chapters Fall 2010
| 1 |
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Aug 30 |
Electrical Properties of Cells, Tissues, and Organs - Overview, Introduction and History: Phenomena and Mechanisms, Diagnostic and Therapeutic Applications |
| 2 |
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Sep 1 |
Biological and Engineering Fundamentals: Morphology and Physiology of Cells, Biological Membranes, Tissues and Organs, Excitable and Non-Excitable Cells |
| - |
|
Sep 6 |
LABOR DAY HOLIDAY |
| 3 |
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Sep 8 |
Biological and Engineering Fundamentals: Electric Circuits and Signals; Circuit Representation of Cells; Electrically Small vs Large Cells |
| 4 |
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Sep 13 |
Bulk Dielectric Characteristic of Cells and Tissues: Permittivity, Conductivity; Dielectric Spectroscopy, Electrophoresis, Applications for Cancer Diagnostics |
| 5 |
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Sep 15 |
Electrical Properties of Cell Membranes: Resting Potential, Nemst Equation, Ion Flow (Channels, Gates, Pumps), Goldman-Hodgkin-Katz Equation |
| 6 |
|
Sep 20 |
Active Behavior of Cell Membranes: Action Potential, Nerve Conduction, Hodgkin-Huxley Membrane Model, Experimental Approaches: Patch-Clamp |
| 7 |
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Sep 22 |
Modeling Of Electric Signals in Excitable Cells |
| 8 |
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Sep 27 |
Introduction into Modeling of Electrical behavior of (non-excitable) cells: Distributed Circuit Models, Molecular Dynamics Simulations |
| - |
|
Sep 29 |
TEST #1 |
| 10 |
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Oct 4 |
Functional Electric Stimulation: Electrotherapy of Muscles and Nerve Fibers |
| 11 |
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Oct 6 |
Electrotherapy in Wound Healing |
| - |
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Oct 12 |
FALL HOLLIDAYS |
| 12 |
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Oct 13 |
Anatomy and Physiology of the Heart |
| 13 |
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Oct 18 |
Electrical Activity and Activation of the Heart |
| 14 |
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Oct 20 |
Theoretical Methods of Analyzing Volume Sources, forward/inverse problem, Miller-Geselowitz Model, Einthoven triangle, Gabor-Nelson Theorem |
| 15 |
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Oct 25 |
The Normal and Abnormal EKG |
| 16 |
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Oct 27 |
Cardiac Pacing, Cardiac Defibrillation |
| 17 |
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Nov 1 |
Electrical Accidents and Injuries |
| 18 |
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Nov 3 |
TEST #2 |
| 19 |
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Nov 8 |
Health Effects from (Ambient) Electromagnetic Radiation: Cell Phones, Power Lines and other Radiofrequency and Microwave Transmitters |
| 20 |
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Nov 10 |
Therapies with Electromagnetic Radiation: Microwave and RF Exposures |
| 21 |
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Nov 15 |
Therapies with Electromagnetic Radiation: Electroporation, Nanosecond Pulsed Electric Field Effects |
| 22 |
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Nov 17 |
Electroporation: Applications for Drug Delivery and Gene Therapy |
| 23 |
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Nov 21 |
Nanosecond Pulsed Electric Fields: Cancer Therapies, Wound Healing |
| - |
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Nov 25 |
THANKSGIVING HOLIDAYS |
| 29 |
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Nov 30 |
Interaction of Cells and Tissues with (Non-Thermal) Plasmas |
| 25 |
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Dec 1 |
Non-Thermal Plasmas - An Introduction into Physics and Chemistry |
| 26 |
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Dec 6 |
Plasmamedicine |
| 27 |
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Dec 8 |
Emerging Frontiers: Pulsed Electric Fields and Plasmas in New Environmental, Medical and Bioengineering Applications |
| 28 |
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Dec 17 |
TEST #3 (Final) |
Juergen Kolb, March 2011
Contributers/Guest-Speakers Fall 2009:
- Dr. Andrei Pakhomov, Center for Bioelectrics, ODU
- Dr. Ravindra Joshi, Dept. Electrical and Computer Engineering, ODU
- Dr. Stephen Beebe, Center for Bioelectrics, ODU
- Dr. Frank Lattanzio, Dept. Pharmacology, EVMS
- Dr. Mounir Laroussi, Laser and Plasma Institute, ODU
- Dr. Loree Heller, Center for Bioelectrics, ODU
- Dr. Karl Schoenbach, Center for Bioelectrics, ODU
- Dr. Shu Xiao, Dept. Electrical and Computer Engineering, ODU
Topics/Chapters Fall 2009
| 1 |
|
Aug 31 |
Electrical Properties of Cells, Tissues, Organs - Overview, Introduction and History: Phenomena and Mechanisms, Diagnostic and Therapeutic Applications |
| 2 |
|
Sep 2 |
Biological and Engineering Fundamentals: Morphology and Physiology of Cells, Biological Membranes, Tissues and Organs, Excitable and Non-Excitable Cells |
| - |
|
Sep 7 |
LABOR DAY HOLIDAY |
| 3 |
|
Sep 9 |
Biological and Engineering Fundamentals: Electric Circuits and Signals; Circuit Representation of Cells; Electrically Small vs Large Cells |
| 4 |
|
Sep 14 |
Bulk Dielectric Characteristic of Cells and Tissues: Permittivity, Conductivity; Dielectric Spectroscopy, Electrophoresis, Applications for Cancer Diagnostics |
| 5 |
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Sep 16 |
Electrical Properties of Cell Membranes: Resting Potential, Nemst Equation, Ion Flow (Channels, Gates, Pumps), Goldman-Hodgkin-Katz Equation |
| 6 |
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Sep 21 |
Active Behavior of Cell Membranes: Action Potential, Nerve Conduction, Hodgkin-Huxley Membrane Model, Experimental Approaches: Patch-Clamp |
| 7 |
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Sep 23 |
Modeling of Electric Cell Characteristics: Equivalent Circuit Models, Electronic Modeling of Excitable Tissue (Lewis Model) |
| 8 |
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Sep 28 |
Electronic Modeling of Cell Membranes: Axon Cable Models, Modeling Approaches: Distributed Circuit Models, Molecular Dynamics Simulations |
| - |
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Sep 30 |
TEST #1 |
| 10 |
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Oct 5 |
Functional Electric Stimulation: Electrotherapy of Muscles and Nerve Fibers |
| 11 |
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Oct 7 |
Electrotherapy in Wound Healing |
| - |
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Oct 12 |
FALL HOLLIDAYS |
| 12 |
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Oct 14 |
Anatomy and Physiology of the Heart |
| 13 |
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Oct 19 |
Electrical Activity and Activation of the Heart |
| 14 |
|
Oct 21 |
Theoretical Methods of Analyzing Volume Sources, forward/inverse problem, Miller-Geselowitz Model, Einthoven triangle, Gabor-Nelson Theorem |
| 15 |
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Oct 26 |
The Normal and Abnormal EKG |
| 16 |
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Oct 28 |
Cardiac Pacing, Cardiac Defibrillation |
| 17 |
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Nov 2 |
Electrical Accidents and Injuries |
| 18 |
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Nov 4 |
TEST #2 |
| 19 |
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Nov 9 |
Electrically Induced Interactions with Cells and Tissues: Plasma, Microwaves/RF-Stimulation, 'Long' vs 'Short' Pulsed Electric Fields, Magnetic Stimulation, ELF-Effects |
| 20 |
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Nov 11 |
Health Effects from Cell Phones and other Radiofrequency Transmitters |
| 21 |
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Nov 16 |
Plasma-Cell Interactions and Applications |
| 22 |
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Nov 18 |
Plasma Medicine |
| 23 |
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Nov 23 |
"Long" Pulsed Electric Fields - Electroporation |
| - |
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Nov 25 |
THANKSGIVING HOLIDAYS |
| 24 |
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Nov 30 |
Electroporation: Applications for 'Drug Delivery, Gene Therapy |
| 25 |
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Dec 2 |
Nanosecond Pulsed Electric Fields - Intracellular Electroeffects |
| 26 |
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Dec 7 |
Nanosecond Pulsed Electric Fields: Cancer Therapies, Wound Healing |
| 27 |
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Dec 9 |
Picosecond High Voltage Pulses for Therapy and Diagnostic |
| 28 |
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Dec 18 |
TEST #3 |
Juergen Kolb, July 2009
mail to: webmaster@pulsedpower.de
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